In today's new issue of JCB, Wen et al. reveal that the development of Alzheimer's disease might be promoted by defective recycling of the enzyme beta-secretase. Vps35 is a component of the retromer complex that transports proteins from endosomes to the Golgi. In the absence of Vps35, cells accumulate extra beta-secretase in their endosomes, where the enzyme may be more active in converting amyloid precursor protein into toxic Abeta peptides. Mice prone to Alzheimer's disease develop neurodegenerative symptoms even quicker if they lack one copy of the VPS35 gene. You can read more in this summary.
Calvert et al. find that large cells divide at a faster rate than small cells in the filamentous fungus Neurospora crassa. The reason seems to be that larger cells start off with a higher amount of myosin II in the contractile ring that separates cells during cytokinesis, which allows the rings to constrict more rapidly. More here.
Karotki et al. demonstrate that the components of eisosomes - protein complexes that spatially organize the plasma membrane - carry out their function by assembling into a lipid-binding filamentous scaffold. As explained in this week's In Focus, Karotki et al. show that, in vitro, eisosome proteins assemble into helical filaments that can re-shape artificial liposomes, suggesting that the proteins may act similarly to remodel the plasma membrane. Indeed, this issue's cover image shows a helical eisosome filament on the cytoplasmic face of the budding yeast plasma membrane.
Lasserre et al. describe how the kinase HPK1 phosphorylates two signaling adaptor proteins in order to disassembly T cell receptor microclusters and switch off T cell signaling. (Summary here). And, sticking with T cells, Zyss et al. reveal that casein kinase I delta helps to reposition the centrosome toward the immunological synapse (where T-lymphocytes contact their target, antigen-presenting cells), perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. You can find out more in this month's biosights, in which senior author Fanni Gergely explains CK1 delta's role in centrosome translocation in more detail...
Lots more interesting papers that I didn't have time to mention here. You can find them all on our table of contents by clicking this link.